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Post-doctoral fellow – CHO cell production of exosomes

The CU Fellows: Integration of Upstream and Downstream Elements of Biotherapeutic Vector Processing. Project focused on the high efficiency isolation of exosomes from mAb-producing CHO cell bioreactors, to derive high-value EVs as by-products.
Organization: Clemson University
Location: South Carolina
Contact: R. Kenneth Marcus – marcusr@clemson.edu
Posted until: 5/1/2024
Employment type: Full time
Organization type: Academic

Full description:

The CU Fellows: Integration of Upstream and Downstream Elements of Biotherapeutic Vector Processing position is a two-year funded appointment that seeks to bring two areas of expertise at Clemson University; CHO cell bioreactor control and operations in the laboratory of Prof. Sarah Harcum (Dept. of Bioengineering) and novel chromatographic methods for exosome isolation in the laboratory of Prof. R. Kenneth Marcus (Dept. of Chemistry).

These two laboratories already have extensive collaborations in place and are in fact in the same research facility. The premise of the position is to have a joint project focused on the high efficiency isolation of exosomes from mAb-producing CHO cell bioreactors. In this way, efforts to derive high-value exosomes as by-products of antibody production will be advanced. The focus is truly towards merging upstream and downstream processes to improve the overall productivity of CHO cell biotherapeutic production.

Descriptions of the respective PI research programs can be found at: https://www.clemson.edu/cecas/departments/bioe/people/directory/harcum.html and https://www.clemson.edu/science/academics/departments/chemistry/about/profiles/marcusr

Qualifications

The successful candidate is expected to hold a Ph.D. degree in fields such as analytical chemistry, biochemistry, chemical engineering, of bioengineering. Their research backgrounds should include aspects of separation science, cell culturing, or bioreactor design/process monitoring. It would be expected that the candidate has a record of scientific publication/presentations.

Application Instructions

Review of applications will begin immediately; however, the position will remain open until filled.

Applicants should submit the following items via Interfolio at http://apply.interfolio.com/140325

  1. Letter of interest
  2. Complete CV
  3. Letter of endorsement from Ph.D. advisor
  4. Additional letter of endorsement from person familiar with candidate’s research


For more information, please contact Prof. R. Kenneth Marcus (marcurs@clemson.edu) and/or Prof. Sarah Harcum (harcum@clemson.edu).

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