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Continuous Cell Culture for Viral Vaccines

Development of a mechanistic model of vaccine production for the development and demonstration of the continuous operation of an upstream cell culture process for the production of a model vaccine.
Categories
Vaccines
Drug product
Project status
100% Completed

Industry Need

  • The biopharmaceutical industry has shown significant interest in developing continuous manufacturing processes for therapeutic protein production. 
  • Despite some progress, continuous manufacturing approaches have yet to be widely applied to cell-culture based vaccine manufacturing. 
  • The production of viral vaccines is more biologically complex than the production of recombinant protein therapeutics because of the infection and replication cycle of the virus. 
  • The development of a first principles/mechanistic model of the manufacturing process could be a key element in the design of a manufacturing process and feedback control system that will allow for extended operation of the production system and consistent effluent of virus titer of high quality


Solution

MIT and participating organizations aimed to create a mechanistic model of vaccine production for the development of the continuous operation of an upstream cell culture process to produce a model vaccine. This approach could be generalizable to a variety of vaccine production systems based upon the characteristics of the host cell line being used and the vaccine being produced.  

Updates, Related Publications, and Deliverables

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Project Lead

Massachusetts Institute of Technology

Massachusetts Institute of Technology

Participating Organizations

Massachusetts Life Sciences Center

Massachusetts Life Sciences Center

Merck Sharp & Dohme LLC

Merck Sharp & Dohme LLC

Repligen Corporation

Repligen Corporation

University of Massachusetts Medical School

University of Massachusetts Medical School

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