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Flow Water Proton NMR as Contact-Free Real-Time In-Line PAT for Continuous Biomanufacturing

This work develops a contact-free real-time in-line process analytical technology (PAT) for biomanufacturing. The technology, flow-wNMR, is based on the nuclear magnetic resonance signal of water. Because water i
Categories
Process control
Project status
100% Completed

Solution

Performance Period: 3/1/2018 to 10/31/2019

This work develops a contact-free real-time in-line process analytical technology (PAT) for biomanufacturing. The technology, flow-wNMR, is based on the nuclear magnetic resonance signal of water. Because water is the solvent in all biomanufacturing processes, flow-wNMR has wide applicability. Flow-wNMR has no contact with the process stream, therefore probe fouling, a fundamental limitation of existing in-line PATs, is completely eliminated. The focus of this project is to integrate flow-wNMR with a continuous protein purification system — countercurrent tangential chromatography. The simplicity, flexibility, affordability and sturdiness of flow-wNMR make it easily adoptable to various floor conditions in biomanufacturing plants.

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Project Lead

University of Maryland Baltimore

University of Maryland Baltimore

Participating Organizations

ChromaTan Corporation

ChromaTan Corporation

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