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Integrated glycan analysis of monoclonal antibodies using UPLC-MS

This project at MassBiologics of University of Massachusetts Medical School will be led by Dr. David McNally and Dr. Tianyuan Peng. This project is part of a larger small group study to evaluate the variability associated with operator-associated variabil
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Assays
Project status
100% Completed

Industry Need

Enhanced and/or standardized ability to measure and quantitatively evaluate the glycan profile of a reference monoclonal antibody 

Solution

The University of Massachusetts will procure a Waters BioAccord LC-MS system. This approach will be used to measure and quantitatively evaluate the glycan profile of a reference monoclonal antibody using glycan standards as well as the glycan profile of a reference monoclonal antibody where the release was performed at a central laboratory.

Outcomes and Impacts

Upon project completion, the Waters BioAccord LC-MS system will be available on a priority basis for NIIMBL-related technology and workforce activities, within any necessary constraints of the host institution, to be negotiated with NIIMBL.

Updates, Related Publications, and Deliverables

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Project Lead

University of Massachusetts System

University of Massachusetts System

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