The University of Delaware will procure an Agilent 1290ii uHPLC, 6545XT Advance Bio Q/TOF. This approach will be used to measure and quantitatively evaluate the glycan profile of a reference monoclonal antibody using glycan standards as well as the glycan profile of a reference monoclonal antibody where the release was performed at a central laboratory.
After this project is completed, the uHPLC-Q/TOF will be available on a priority basis for NIIMBL-related technology and workforce activities, within any necessary constraints of the host institution, to be negotiated with NIIMBL.
Assess whether “community performance metrics” can be defined for NISTmAb released and/or released/labeled methods
Evaluate modes of implementation of a new quantitative glycan standard, SRM 3655
Determine if SRM 3655 can assist in harmonizing or standardizing glycan measurements
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University of Delaware