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Noninvasive PAT for Aluminum-adjuvanted Vaccines

This project will develop a real-time, non-invasive process analytical technology for biopharmaceutical products using nuclear magnetic relaxation of water. wNMR is a true platform technology for biomanufacturing.
Categories
Proteins/ Antibodies
Vaccines
Process control
Project status
100% Completed

Solution

Performance Period: 2/3/2020 to 12/31/2021

This project will develop a real-time, non-invasive process analytical technology for biopharmaceutical products using nuclear magnetic relaxation of water. Because water is the solvent for all bioprocessing operations and all biologic products, wNMR is a true platform technology for biomanufacturing, both for process monitoring and product inspection. This technology will be used to characterize the aluminum-antigen adsorption process and evaluate the stability of antigen-aluminum complex under stress. This non-invasive, real-time approach limits contamination and enables uninterrupted manufacturing operation reducing time and cost. 

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Project Lead

University of Maryland Baltimore

University of Maryland Baltimore

Participating Organizations

Merck Sharp & Dohme LLC

Merck Sharp & Dohme LLC

Pfizer, Inc.

Pfizer, Inc.

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