Buffer Stock Blending System

In collaboration with BioPhorum, NIIMBL has designed, built, and tested a full-scale, current good manufacturing practices (cGMP) system that is able to deliver buffer on-demand.

The challenge: Improve buffer preparation methods

Buffer solutions are key components in the manufacture of therapeutic proteins. However, buffer preparation presents a significant bottleneck in the process. Current preparation methods are slow, labor-intensive, and require large footprints on manufacturing floors. 

The solution: The NIIMBL BioPhorum Buffer Stock Blending (BSB) System

  • The NIIMBL BioPhorum BSB System has an open configurable design, and accurate mass flow control with modern automation and visualization, to deliver buffers over a wide range of flow rates.  
  • Developed by a diverse team of industry experts, the NIIMBL-BioPhorum BSB System revolutionizes buffer preparation by providing the industry with a system designed, built, and tested to deliver buffer on-demand at a commercial scale, with significant cost savings in labor and cost per liter compared to traditional buffer preparation. 
  • The NIIMBL BioPhorum Buffer Stock Blending System prototype model is currently located at the NIIMBL headquarters in Newark, Delaware. 

Buffer Stock Blending System benefits

  • Increases speed of buffer preparation
  • Less labor intensive
  • Reduces capital costs
  • Reduces footprint on manufacturing floor
Buffer prepared in <1 hour
0 L
Time reduction
> 0 %
Floor footprint reduction
0 %

Learn more about the BSB System

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