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Case Studies

NIIMBL is committed to supporting and accelerating the adoption of advanced manufacturing technologies. Read summaries and highlights of completed projects.

Technology Projects

December 2023

Single-use Modules for Continuous Removal of Antibody Fragments

LigaTrap Technologies, LLC, Merck & Co., Inc., MilliporeSigma/EMD Serono, North Carolina State University, Rensselaer Polytechnic Institute

November 2022

Noninvasive PAT for Aluminum-adjuvanted Vaccines

Merck & Co., Inc., Pfizer, Inc., University of Maryland Baltimore

September 2022

Specific Detection of Infected Cells Using Optical Drag-Tags in Laser Force Cytology

Carnegie Mellon University, LumaCyte, Merck & Co., Inc., Rensselaer Polytechnic Institute

September 2022

International Assessment of PSPT in Mice to Replace the Intracerebral-challenge Mouse Protection Test (MPT) for Whole-cell Pertussis (wP)

Developing Countries Vaccine Manufacturers Network (DCVMN)

July 2021

A Multivariate In-Line Optochemical Sensor Platform for Continuous Monitoring of Cross-Category Process Parameters and Product Attributes in Bioreactors

MilliporeSigma / EMD Serono, North Carolina State University, Pfizer, Inc.

June 2021

NIIMBL-BioPhorum Buffer Stock Blending System

Merck & Co., Inc., MilliporeSigma, Janssen Research & Development, LLC, Sanofi, GlaxoSmithKline, and others

April 2021

Software and Hardware Tools for Pharmaceutical Lyophilization Scale-up

Physical Sciences, Inc., University of Massachusetts Lowell, National Institute for Pharmaceutical Technology and Education, Inc. (NIPTE) (Uconn), Massachusetts Life Sciences Center, Purdue University, Merck & Co., Inc., Genentech

January 2021

Low-cost Production and Purification of Cytokines and Growth Factors for Cell Therapy Products

Potomac Affinity Proteins, University of Maryland College Park

December 2020

Development of a Microchip CE-HPMS Analyzer for Bioreactor Monitoring

Bristol-Myers Squibb, MilliporeSigma, North Carolina State University, University of North Carolina, Chapel Hill,  908 Devices

September 2020

Blaze Microchip System for Real-time Characterization of Intact Biopharmaceuticals

Intabio, Inc., Merck & Co., Inc., MilliporeSigma, Bristol-Myers Squibb, Genentech

Workforce Development Projects

May 2023

Workforce Expansion in Biomanufacturing Emerging Technologies

Montgomery County Community College, Solano College, MiraCosta College, Quincy College, Forsythe Tech, Shoreline Community College

February 2023

Modularized PAT Online Training Platform to Accelerate the Workforce Innovation in Biopharmaceuticals Manufacturing

Northeastern University, Massachusetts Institute of Technology, Genentech, Merck & Co., Inc., Janssen, Sartorius

February 2022

WORDE: A Biopharmaceutical Training Center to Promote Development of the Workforce, Outreach, Research, Diversity, and Education

Delaware State University, Merck & Co., Inc., Montgomery County Community College

January 2022

Military Service Members in Biopharma Manufacturing (MSMBM)

Texas A&M University, North Carolina Biotechnology Center, Central Carolina Community College, Durham Technology Community College, Merck & Co., Inc., and Pfizer, Inc.

March 2021

Bridging the Gap: A Biopharmaceutical Processing Workforce Development Continuum

Thomas Jefferson Institute for Bioprocessing, Montgomery County Community College, Bucks County Community College, Merck & Co., Inc.

September 2019

Reducing Door to Floor: Improving Readiness of New Hires Through cGMP Hands-on Biopharmaceutical Training

Texas A&M University, Vericel Corporation, Akron Biotechnology

American Rescue Plan

August 2023

A New Generation of High-efficiency HVAC Filters that Can Be Used with Existing Infrastructure to Stop the Spread of Coronavirus Through Recirculation of Air

North Carolina State University

August 2023

Development of a Thermo-tolerant, Multidose, Egg-produced, Vector-based Coronavirus Vaccine

PATH Center for Vaccines Innovation & Access

August 2023

Development of Scalable, Thermostable, Spray Dried Vaccine Formulations Applicable for Coronavirus Vaccines

Fraunhofer USA

CARES Act Projects

October 2021

Designing a Tesk Kit Supply Chain in Response to COVID-19

North Carolina State University

October 2021

Development of a SARS-COV-2 Polyvalent Microbead Immunoassay (MIA)

New York State Department of Health (Wadsworth Center), MassBiologics of UMass Chan Medical School

March 2021
Production of N95 and Surgical Masks at the Nonwovens Institute (NWI), North Carolina State University
North Carolina State University

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