Associate Vice President / Vice President, Lead Optimization Mass Spectrometry

“Lead from the Bench” by actively participating in the team’s research activities with a focus on developability assessment and optimization of drug candidates (i.e., hands-on experimental work, experimental design, advanced data analysis, etc.)
Organization: Eli Lilly and Company
Location: Indiana
Posted until: 11/13/2025
Employment type: Full time
Organization type: Industry

Full description:

Responsibilities:

  • “Lead from the Bench” by actively participating in the team’s research activities with a focus on developability assessment and optimization of drug candidates (i.e., hands-on experimental work, experimental design, advanced data analysis, etc.)
  • Build mass spectrometry-based solutions and proactively drive innovation by developing cutting edge LC-MS technologies and workflows to meet the challenges of a growing and complex large-molecule portfolio (e.g., monoclonal antibodies, bispecific antibodies, fusion proteins, antibody-drug conjugates, peptides, oligonucleotides, viral and non-viral nanoparticles, etc.)
  • Leverage extensive knowledge of and experience with a broad range of characterization methods to inform lead optimization (e.g., intact mass analysis, identification of post-translational modifications, profiling molecule assembly and structural variants including disulfide mapping, identifying glycosylation patterns, etc.) 
  • Utilize expert-level proficiency in a wide range of industry-standard mass spectrometry data processing and analysis software platforms including Genedata Expressionist.
  • Build effective partnerships with teams within BioTDR and across the broader discovery and development network and provide broad scientific leadership.
  • Mentor and coach scientists to think deeply, work creatively, and deliver scientific excellence to drive projects to key decision points and milestones.
  • Maintain strong engagement with the external scientific community through academic literature, collaborations/partnerships, active participation in technical meetings/consortia, and other professional networking.

Basic Requirements:

  • Ph.D. in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or related discipline.
  • 15+ years academic, research institute, or industry experience with mass spectrometry and separation sciences towards the characterization of proteins and peptides.
  • Demonstrated ability to create and sustain a world-class biologics mass spectrometry laboratory and champion a culture of innovation, inclusion, collaboration, and scientific excellence.

Additional Skills/Preferences:

  • Proven track record of partnering with third parties for the development of cutting-edge hardware and software
  • Working knowledge of the large-molecule drug discovery, optimization, and development process.
  • Promoting a culture of safety in the workplace.
  • A record of scientific achievement as demonstrated by a strong publication record, presentations at external conferences, and patents
  • Strong verbal and written communication skills
  • Excellent time management and organizational skills with the ability to adapt to changing priorities and deadlines.
  • Working effectively across organizational boundaries to navigate complex business and technical issues.
  • Ability to lead individuals and teams through direct and indirect reporting structures.
  • Data analytics experience with Benchling.

Additional Information:

  • Location: Indianapolis, Indiana
  • Travel: 0-10%

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

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Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is

$205,500 – $301,400

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Eli Lilly and Company