A Multivariate In-Line Optochemical Sensor Platform for Continuous Monitoring of Cross-Category Process Parameters and Product Attributes in Bioreactors

Performance Period: 2/1/2020 to 7/31/2021

This project develops a multi-attribute inline optochemical sensor platform for continuous monitoring of bioreactors at all scales. This multiplexed fiber-optic sensor platform will monitor, for the first time, cross-category variables, such as metabolites (e.g., glucose), dissolved O2 (DO) or dissolved CO2 (DCO). This technology will shorten conventional analytical tests for bioreactors from multiple days to real-time, which is a critical step toward ultimate closed feedback control loops that enable continuous and adaptable manufacturing.