Rensselaer aims to purify labile mRNA quickly at high yield and purity in a continuous production mode to increase quality and reduce production time and cost. The team’s approach is to replace resin-based chromatography with adsorptive membranes.
The project will purify mRNA from a synthetic in vitro transcription (IVT) feed using an affinity membrane process and comparing the performance with commercial affinity chromatography bead column.
The project will also demonstrate the affinity membranes can purify mRNA with similar purity and yield but a faster rate with smaller equipment setup by
This project will increase quality, reduce production time and cost by speeding up as well as facilitating continuous production and purification of mRNA vaccines for other virus infections by converting from chromatographic to membrane-based separations.
Not yet a member? Learn more about which level of NIIMBL membership is right for you and your organization.