In this project, NC State University will:
Will enable improved methods for the routine production and analysis of mRNA vaccine products, which will play a critical role in global pandemic preparedness and response
Provide a new method for in situ product recovery which will reduce costs, increase production efficiency, and alleviate supply chain issues
Help study the effect of novel uridine chemistries and reaction conditions to optimize the synthetic rate and minimize the side products associated with the in vivo translation process
Set the stage for further studies on potential avenues for continuous mRNA vaccine manufacturing
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North Carolina State University