Acquisition and Benchmarking of a Perkin Elmer LabChip CXII Touch Protein Characterization System

This project at Carnegie Mellon University will be led by Prof. Anne S Robinson. This project is part of a larger small-group study to evaluate the variability associated with operator-associated variability in measuring released glycans from a monoclonal
Categories
Assays
Equipment and Supplies
Data
Project status
100% Completed

Industry Need

  • Recipient of funding for NIIMBL Project Call 5.1, which involves projects that help determine the variability associated with key product attributes for therapeutic proteins such as recombinant monoclonal antibodies while investing in state-of-the-art analytical instrumentation infrastructure that will be available across our community to support NIIMBL-related activities in the future in this and related technical areas. 

Solution

The team will procure a Perkin Elmer LabChip CXII Touch Protein Characterization System. The system will be used to measure and quantitatively evaluate the glycan profile of a reference monoclonal antibody using glycan standards as well as the glycan profile of a reference monoclonal antibody where the release was performed at a central laboratory. 

Outputs/Deliverables

  • Purchase and install Perkin Elmer LabChip GXII Touch Protein Characterization System
  • Carry out analysis of 13 glycan calibrants provided by NIIMBL and antibody samples, performed at least in triplicate


Impacts

At project completion, the LabChip System will be available on a priority basis for NIIMBL-related technology and workforce activities, within any necessary constraints of the host institution, to be negotiated with NIIMBL.

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Project Lead

Carnegie Mellon University

Carnegie Mellon University