Bioprocess Online Training using Digital Twin (BOT-DT)

OUTPUTS

• The project accomplished two key innovations. First, a comprehensive bioprocessing curriculum was designed, developed, and tailored to workforce needs through a diverse Curriculum Advisory Committee. Second, an accessible online learning platform was created with an immersive digital twin environment enabling autonomous, self-directed learning. 
• The curriculum covers foundational upstream and downstream concepts from cell culture through purification following industry standards. Assessments directly map to defined learning objectives for skill-based competencies.
• The online platform combines engaging multimedia learning modules with cutting-edge digital twin simulation using virtual reality. The digital twin environment allows learners to apply knowledge in a realistic setting and build skills through hands-on practice. Key advantages of digital twins include:
  • Always up to date: Virtual equipment reflects the latest configurations
  • Accessible anytime: Available 24/7 for self-directed learning
  • Easily distributed: Centrally hosted and accessible from anywhere
  • Edge case exploration: Failures and risks impossible to replicate physically.
  • Structured learning prompts guide autonomous training, providing interactive standard operating procedures for equipment usage.
  • The ability to intentionally introduce problems and errors builds robust troubleshooting skills.
•  Additionally, the team formally evaluated the educational approach through an IRB-approved study protocol with 36 students. The beta testing investigation generated an outcomes report to refine the curriculum and platform.
• This commitment to evidence-based improvement will strengthen follow-on programs that should focus on the connection of the virtual training to the real world, i.e. train students in VR and then assess them on physical equipment for the same tasks.