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Bioprocess Online Training using Digital Twin (BOT-DT)

Team to use HakoBio platform to build a Digital Twin for one upstream operation (rocker bioreactor) and one downstream operation (tangential flow filtration/TFF) as proof-of-concept.
Categories
Talent/ Pipeline development
Project status
100% Completed

Solution

Performance Period: 9/1/2021 to 5/31/2023

Keck Graduate Institute (KGI), OUAT!, Santa Clara University (SCU), Cal Poly (CP), Merck, Catalent and Sartorius are partnering to develop blended training resources using video, animation and virtual reality. These modules will engage students in online courses, while providing a simulated hands-on experience.

Remote education approaches have become critical to delivering a skilled biopharmaceutical manufacturing workforce. These tools will provide sustainable benefit beyond the pandemic response, providing the biopharmaceutical industry with access to lower cost, on-demand training with no travel expenses.

Traditionally, individualized training modules have been poorly suited for fast evolving educational needs. Recent developments in virtual reality for equipment design can be leveraged to replicate the practical sessions with customized facility simulations which are vital in developing proficiency for complex operations.

Through collaboration with OUAT!, we will use the HakoBio platform to build a Digital Twin for one upstream operation (rocker bioreactor) and one downstream operation (tangential flow filtration/TFF) as proof-of-concept. Process data will be integrated into the Digital Twin to provide real-time scenario training. Small groups of students will complete the modules at KGI, SCU and CP and knowledge and skills assessments will be completed to determine learning and retention provided by the new modules.

Outcomes and Impacts

Blended training resources created using video, animation, and virtual reality. These modules will engage students in online courses while providing a simulated hands-on experience.

A HakoBio platform builds a Digital Twin for one upstream operation (rocker bioreactor) and one downstream operation (tangential flow filtration/TFF) as proof-of-concept.

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Project Lead

Keck Graduate Institute

Keck Graduate Institute

Participating Organizations

California Polytechnic State University

California Polytechnic State University

Catalent Pharma Solutions, LLC

Catalent Pharma Solutions, LLC

Merck Sharp & Dohme LLC

Merck Sharp & Dohme LLC

OUAT!

OUAT!

Santa Clara University

Santa Clara University

Sartorius Stedim

Sartorius Stedim