Develop software for next-generation N- and O-linked glycosylation mechanistic models for control for fed-batch Chinese Hamster Ovary (CHO) cell culture
Categories
Proteins/ Antibodies
Drug substance
Process control
Data
Project status
100% Completed
Industry Need
Laboratory experiments increase new product development cost.
Solution
Use Glycosylation modeling to reduce laboratory experimentation
Outputs/Deliverables
Modelling Software in Open-Source platform (done)
Model Use Training documentation (done)
Publication – Recurrent Neural Network-based Prediction of the Location of O-GlcNAcylation Sites in Mammalian Proteins (Seber, Braatz (MIT)) http://dx.doi.org/10.1101/2023.08.24.554563
Publication – Linear and Neural Network Models for Predicting N-glycosylation in Chinese Hamster Ovary Cells Based on B4GALT Levels (Seber, Braatz (MIT)) http://dx.doi.org/10.1101/2023.04.13.536762
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