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Cell separation, processing, and expansion for cell therapy applications

The team plans to develop an innovative technology platform for cell therapy manufacturing that can accommodate all the necessary unit operations, including separation of cell phenotypes, activation and transduction, and expansion of purified phenotypes.
Categories
Cell and Gene therapies
Equipment and Supplies
Process control
Project status
100% Completed

Solution

Performance Period: 9/1/2020 to 2/28/2022

We propose to develop an innovative technology platform for cell therapy manufacturing that can accommodate all the necessary unit operations, including separation of cell phenotypes, activation and transduction, and expansion of purified phenotypes. The proposed device is a flow system based on existing membrane technology, allowing facile scaling and sufficient versatility for provision of nutrients and oxygen, as well as convective enhancement of vector transport for transduction. A unique feature is the integration of tailorable soft materials that will provide optimal microenvironments to facilitate and control cell capture, release, manipulation, and promotion of desired functions.

The initial project period proposed here will be devoted to device construction, optimization of cell microenvironments for different operations, and integration of different unit operations, including testing in realistic manufacturing environments in industry partner labs. We expect that the proposed technology will be enabling for many of the steps necessary for current and emerging forms of cell therapy.

Outcomes and Impacts

Develop an innovative technology platform for cell therapy manufacturing that can accommodate all the necessary unit operations, including separation of cell phenotypes, activation and transduction, and expansion of purified phenotypes

Integration of tailorable soft materials that will provide optimal microenvironments to facilitate and control cell capture, release, manipulation, and promotion of desired functions

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Project Lead

University of Delaware

University of Delaware

Participating Organizations

Merck Sharp & Dohme LLC

Merck Sharp & Dohme LLC

MilliporeSigma/EMD Serono

MilliporeSigma/EMD Serono