Integrated glycan analysis of monoclonal antibodies using UPLC-MS
This project at MassBiologics of University of Massachusetts Medical School will be led by Dr. David McNally and Dr. Tianyuan Peng. This project is part of a larger small group study to evaluate the variability associated with operator-associated variabil
Categories
Assays
Project status
100% Completed
Industry Need
Enhanced and/or standardized ability to measure and quantitatively evaluate the glycan profile of a reference monoclonal antibody
Solution
The University of Massachusetts will procure a Waters BioAccord LC-MS system. This approach will be used to measure and quantitatively evaluate the glycan profile of a reference monoclonal antibody using glycan standards as well as the glycan profile of a reference monoclonal antibody where the release was performed at a central laboratory.
Impacts
Upon project completion, the Waters BioAccord LC-MS system will be available on a priority basis for NIIMBL-related technology and workforce activities, within any necessary constraints of the host institution, to be negotiated with NIIMBL.
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