Currently, there is no contact-free in-line PAT in biomanufacturing and no noninvasive product inspection technology.
Provide a platform technology (wNMR) for product release inspection and continuous process monitoring as well as at the fill-finish step of manufacturing process.
Monitor adsorption of aluminum adjuvants to antigen in real-time and noninvasively using non-flow wNMR.
Measure kinetics of antigen-alum adsorption reaction with kon and koff.
Taraban, M. B., Briggs, K. T., Yu, Y. B., Jones, M. T., Rosner, L., Bhambhani, A., Williams, D. M., Farrell, C., Reibarkh, M., & Su, Y. (2023). Assessing Antigen-Adjuvant Complex Stability Against Physical Stresses By wNMR. Pharmaceutical Research, 40(6), 1435-1446. https://doi.org/10.1007/s11095-022-03437-1
Yu, Y. B., Briggs, K. T., & Taraban, M. B. (2023). Preventive Pharmacovigilance: timely and precise prevention of adverse events through person-level patient screening and dose-level product surveillance. Pharmaceutical Research, 40(9), 2103-2106. https://doi.org/10.1007/s11095-023-03548-3
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University of Maryland Baltimore
Merck Sharp & Dohme LLC
Pfizer, Inc.
