Performance Period: 2/3/2020 to 12/31/2021
This project will develop a real-time, non-invasive process analytical technology for biopharmaceutical products using nuclear magnetic relaxation of water. Because water is the solvent for all bioprocessing operations and all biologic products, wNMR is a true platform technology for biomanufacturing, both for process monitoring and product inspection. This technology will be used to characterize the aluminum-antigen adsorption process and evaluate the stability of antigen-aluminum complex under stress. This non-invasive, real-time approach limits contamination and enables uninterrupted manufacturing operation reducing time and cost.
Monitor adsorption of aluminum adjuvants to antigen in real-time and noninvasively using non-flow wNMR.
Measure kinetics of antigen-alum adsorption reaction with kon and koff.
Taraban, M. B., Briggs, K. T., Yu, Y. B., Jones, M. T., Rosner, L., Bhambhani, A., Williams, D. M., Farrell, C., Reibarkh, M., & Su, Y. (2023). Assessing Antigen-Adjuvant Complex Stability Against Physical Stresses By wNMR. Pharmaceutical Research, 40(6), 1435–1446. https://doi.org/10.1007/s11095-022-03437-1
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University of Maryland Baltimore
Merck Sharp & Dohme LLC
Pfizer, Inc.
