Rapid CHO Transcriptome Analysis for Adventitious Agent Detection

The goal of this project is to apply existing genomic analysis technologies to identify changes in miRNA expression in CHO that could be used to assay infection by adventitious agents (AA).
Categories
Assays
Project status
100% Completed

Industry Need

Current methods to reveal information on the health and productivity of cells used in the biomanufacturing processes include laborious processes steps and take several days to for analysis.

Solution

Apply existing genomic analysis technologies to identify changes in miRNA and/or mRNA expression in CHO that could be used to assay infection by adventitious agents. 

Outputs/Deliverables

Discovered a set of miRNA biomarkers whose expression levels correlate with adventitious viral infection.

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Project Lead

Carnegie Mellon University

Carnegie Mellon University

Participating Organizations

MilliporeSigma/EMD Serono

MilliporeSigma/EMD Serono

Rensselaer Polytechnic Institute

Rensselaer Polytechnic Institute