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Rapid Continuous Production of Room Temperature Stable mRNA Vaccines

The goal of this project is to produce continuous automated compact mRNA producing machine, mRNA with improved stability and thermostabilized vaccine unit as output.

Industry Need

  • The COVID-19 pandemic demonstrated the need for readily available mRNA vaccines that do not require ultra-cold storage. 


UMass, Sepragen and the University of Pennsylvania will create a continuous, automated, compact mRNA producing machine.  

To do this, the team will:  

  • Produce a mRNA purification device, inline UV sensor to feedback control and maintain set point concentrations.  
  • Build algorithms and control strategies that utilize biosensor signals in an algorithm for overall feedback control.  


All these tasks at the conclusion of the project will be integrated to successfully produce continuous purification platform for Mab production.

Updates, Related Publications, and Deliverables

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Project Lead

University of Massachusetts System

University of Massachusetts System

Participating Organizations

Sepragen Corporation

Sepragen Corporation

University of Pennsylvania

University of Pennsylvania