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Spectro-acoustic Process Analytical Technology for Continuous Manufacturing of Coronavirus Vaccine

This project aims to demonstrate Raman spectroscopy and acoustic microfluidics in enabling PAT to detect and quantify virus-like particles and attenuated live viruses to aid the continuous manufacturing of vaccines for future coronavirus.

Industry Need

  • Viral epidemics and pandemics require rapid development and manufacturing of vaccines to limit the spread of the disease and minimize loss of life.  
  • Rapid production of vaccines requires standardization processes for controlling the quality of the product. 
  • Current methods for determining the formulation of attenuated live viruses and virus-like particles are limited because they cannot provide real-time information. 


Process analytical technology aims to improve biomanufacturing by providing real-time information about the product, enabling real-time release. This team will use of spectroscopy techniques for continuous in-process monitoring of virus particles and establish the basis for a standardized detection method. Doing so will establish a standard method that follows FDA guidance for future manufacturing of vaccines and address the need for uniform and controlled platform approaches

Outcomes and Impacts

Successful completion of the project will lead to a spectro-acoustic process analytical technology that enables real-time quantification of virus particles necessary for continuous manufacturing of future vaccines towards coronaviruses.

Updates, Related Publications, and Deliverables

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Project Lead

Purdue University

Purdue University