System for RAPID Testing of BIOBURDEN or STERILITY with Automated Imaging

Mango has a technology for detecting microbial growth in hours that is non-destructive of the sample; the electronic Petri dish, or ePetri. This project will update the consumables, design, & software and demonstrate performance of ePetri.
Categories
Proteins/ Antibodies
Vaccines
Cell and Gene therapies
Assays
Project status
100% Completed

Industry Need

  • While sterility and bioburden testing are essential to the quality control process for biopharmaceuticals, it can often take significant time to generate results. 
  • Pharmaceutical microbiologists and the entire supply chain often must wait from days to weeks for results, creating a bottleneck in biomanufacturing and the release process.  


Solution

Mango has an exclusive licensed based technology detecting microbial growth in hours that is non-destructive of the sample: the electronic Petri dish, or ePetri.  

  • ePetri is an automated method for detecting growth and counting individual microorganisms on the surface of an agar-containing plastic consumable. Using sophisticated lenseless image capture and analysis, microbiologists can quickly count micro-colonies emerging from culturable individual microbial cells (i.e., growth-based technology) within a few hours, a full 1 to 3 days sooner than is possible by means of the naked eye.  
  • ePetri uses the same media, filters, plastics, and visual readout that the industry and regulators have trusted for 75 years.  
  • ePetri has the potential to revolutionize how biopharmaceutical bioburden and sterility tests are performed.  

Outputs/Deliverables

  • Reduced time to results for visualizing microbial growth from days to hours.
  • Patented technology eliminated need for external incubators.

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Project Lead

Mango Inc.

Mango Inc.

Participating Organizations

Janssen Research & Development, LLC

Janssen Research & Development, LLC