Testbed for Improving Productivity and Quality of mRNA Vaccines
The goal of this project is to develop an innovative and efficient purification method for production of mRNA vaccines.
Categories
Vaccines
Industry Need
Industries producing mRNA vaccine technology must be prepared to respond rapidly and effectively to future pandemics
Such a rapid response could be facilitated by more readily available infrastructure and methodologies for production and characterization of RNA products
Solution
In this project, NC State University will:
Develop an in-situ mRNA product recovery downstream process based on a simulated moving bed (SMB) approach, using affinity chromatography supports.
Create a testbed that includes production and purification of RNA using in vitro transcription reactions, purification of mRNA using affinity chromatography, and characterization of the final product.
Create materials for hands-on and online training related to the process and the testbed, which can serve as the basis for professional and academic training programs.
Outputs/Deliverables
Develop an in situ mRNA product recovery downstream process based on a simulated moving bed (SMB) approach, using affinity chromatography
Establish a testbed at BTEC, NC State University for production, purification and characterization of RNA
Provide hands-on and online professional and academic training programs
Manufacture RNA samples and/or reagents at small scale
Additional Project Information (Members Only)
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