MilliporeSigma partnered with Metalytics, Inc. to integrate metabolic flux analysis (MFA) into a diagnostic kit that can be used to identify best media composition quickly and effectively for a given CHO cell line.
To do this MilliporeSigma and Metalytics:
Metabolic Flux Analysis (MFA) was added to services MilliporeSigma can offer for media optimization for CHOZN and CHOK-1 cell lines. More development and validation in a broader range of cell lineages is required for predicting the best feed for design of a "kit".
Created a guided metabolic profiling toolkit that can help streamline identification of optimal CHO cell media formulations
Reduced media development screening costs by using a predicted "best fit" medium formulation for CHO cell clonal groups
Furthered understanding of CHO cell metabolism variability across a wide selection of cell lines
Increased ability to use this knowledge to improve media and develop better culture processes, resulting in faster and better methods to improve productivity of recombinant proteins etc. in CHO cultures
Demonstrated the utility of MFA as a tool to accelerate media optimization
Determined that nearly all clones regardless of genetic background have different metabolic profiles
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MilliporeSigma/EMD Serono
Metalytics
