The analysis of host-cell proteins (HCPs) is a route to more fine-grained insights into cell culture and purification of existing products and is likely to aid development of new modalities such as cell therapies. Proteomics technologies, particularly liquid chromatography – mass spectrometry (LC-MS) approaches, enable HCP analysis, and their availability will allow more routine characterization of HCPs that may pose challenges to the industry and development of new methods for HCP analysis.
This project team proposes the creation of a NIIMBL Center of Excellence in HCPs that can support the development and testing of state-of the-art and emerging methods for HCP analysis using mass spectrometry. Such a Center can also serve as a NIIMBL "core facility" for performing HCP analysis in support of NIIMBL Projects and Organizations.
Standardized mass spectrometry-based methods for HCP detection
Support for routine HCP analysis
Center of Excellence in Host-Cell Protein Analysis (SP1.0-004), NIIMBL Member Forum, Virtual, November 29, 2018.
Lenhoff, A., Center of Excellence for Host-Cell Protein Analysis, NIIMBL National Meeting, Washington, DC, June 28, 2019.
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University of Delaware
