Processes developers don’t know the sustainability impact of their decisions because modeling carbon footprint requires special expertise, significant effort, and there is no accepted standard method.
Develop simple, easy-to-use approximate models suitable for use by process developers.
Sustainability of options for new processes and plants are known as design and development decisions are made, leading to more sustainable processes and plants
By utilizing the models developed in this project, an organization can reduce facility energy demand enabling significant carbon footprint reduction, improved throughput, and progress toward net-zero sustainability goals.
LCA Modeling Tool (available now to PI Program participants)
Biosolve Modeling Tool (available now to PI Program participants)
Biosolve Publication (In organization review)
LCA Publication (In progress)
Connell-Crowley, L., Presenter, Environmental Impact Evaluation using LCA, Integrated Continuous Biomanufacturing Conference, Leesburg, Virginia, October 20, 2024.
D'Aquila, D., Presenter, Life Cycle Assessment (LCA) Tool for Evaluating Environmental Impact of mAb Drug Substance Manufacturing, NIIMBL National Meeting, Washington, DC, June 24, 2025.
Hamilton, K., Presenter, Reduce energy usage for Drug Substance Facilities: Development and application of models, BioProcessing Summit, Boston, Massachusetts, August 19, 2025.
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Genentech, Inc.
Amgen Inc.
AstraZeneca
Bristol-Myers Squibb
Cytiva
EMD Millipore Corporation
Eli Lilly and Company
GlaxoSmithKline, LLC
Merck Sharp & Dohme LLC
Pfizer, Inc.
Sanofi
Sartorius Stedim
Takeda Pharmaceuticals
