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Gene Therapy Training Network (GTTN) and Instructional Transfer Platform (ITP)

The Gene Therapy Training Network (GTTN) will enable development of courses related to gene therapy, transfer of these courses to other NIIMBL members, and standardization of course content and curriculum for professionals.
Categories
Cell and Gene therapies
Drug substance
Incumbent worker training
Project status
100% Completed

Solution

Performance Period: 11/1/2019 to 10/31/2021

Despite the growth in gene therapy, there are limited opportunities for training in the area of gene therapy vector manufacturing. This project seeks to change that by developing the Gene Therapy Training Network (GTTN). The network will enable development of courses related to gene therapy, transfer of these courses to other institutions within the National Institute for Innovation in Manufacturing Biopharmaceuticals (NIIMBL), and standardization of course content and curriculum for professionals.

To initiate the network, the Biomanufacturing Training and Education Center (BTEC) at North Carolina (NC) State University will transfer its course on vector manufacturing, Hands-On cGMP Biomanufacturing of Vectors for Gene Therapy, to the National Center for Therapeutics Manufacturing at Texas A&M University. (This course was developed by BTEC under a previous NIIMBL-funded) The two institutions will then work collaboratively to build a technology transfer protocol and model for instructional sharing that can be used to support transfer of other courses within the GTTN and the larger NIIMBL community.

By facilitating collaboration and sharing of curriculum across higher education institutions, the GTTN offers tremendous value. This is especially true for gene therapy, as course content in the field is still under development by educators.

Impacts

Transfer of the "Hands-On cGMP Biomanufacturing of Vectors for Gene Therapy" course to other institutions and regions, enabling opportunities for employees to develop skills in the complex processes required for cGMP production of gene therapy vectors

Development of comprehensive set of courses related to gene therapy, and standardization of gene therapy course content and curriculum for professionals

Publications

Overton, L., Boi, C., Shastry, S., Smith-Moore, C., Balchunas, J., Sambandan, D., & Gilleskie, G. (2023). Development and Delivery of a Hands-On Short Course in Adeno-Associated Virus Manufacturing to Support Growing Workforce Needs in Gene Therapy. Human Gene Therapy, 34(7-8), 259–272. https://doi.org/10.1089/hum.2022.235

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Project Lead

North Carolina State University

North Carolina State University

Participating Organizations

Texas A&M University System

Texas A&M University System