Current industrial practice includes frequent solution sampling and sensor probe calibration in order to monitor solution status such as pH and glucose.
Short wavelength infrared (SWIR) hyperspectral imaging has the potential to offer non-invasive and continuous monitoring solution status to cut labor cost and sampling waste in the processing lines.
Automated system for in-line, non-invasive, self-calibrated pH and/or related DO and glucose measurement in pharmaceutical processing.
By implementing non-invasive hyperspectral monitoring, an organization could reduce labor and sampling costs by minimizing manual checks, enabling automated, cost-efficient biopharmaceutical production.
Show that analytical method SWIR Hyperspectral Imaging (HIS) can predict pH and glucose concentration in aqueous solutions with R2 values larger than 0.9.
Create an innovative system and experiments to gain know-how of a new probe.
Test the new system in labs with partner participations.
Hevaganinge, A., Weber, C. M., Filatova, A., Musser, A., Neri, A., Conway, J., Yuan, Y., Cattaneo, M., Clyne, A. M., & Tao, Y. (2023). Fast-Training Deep Learning Algorithm for Multiplex Quantification of Mammalian Bioproduction Metabolites via Contactless Short-Wave Infrared Hyperspectral Sensing. ACS Omega, 8(16), 14774-14783. https://doi.org/10.1021/acsomega.3c00861
Tao, Y., Wang, D., Wang, C., Hevaganinge, A., Woodard, B., Sawyer, J., Clyne, A., Cattaneo, M., Naryanan, A., & Rummel, N., Non-Contact pH and Glucose Sensing using Short Wavelength Infrared Hyperspectral Imaging, 2021 NIIMBL Member Forum, Virtual, March 25, 2021.
Wang, C., Hevaganinge, A., Wang, D., Ali, M., Cattaneo, M., & Tao, Y., Prediction of Aqueous Glucose Concentration Using Hyperspectral Imaging, 2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), Virtual, November 1, 2021.
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University of Maryland College Park
Artemis Biosystems Inc.
Genentech, Inc.
