Multi-Analyte In-line Sensor for Biomanufacturing Applications Based on Analyte-Responsive Smart Hydrogels.

Applied Biosensors LLC in collaboration with Merck & Co., Inc. and MilliporeSigma, is developing InSens4™, an in-line multi-analyte sensor that can simultaneously monitor Glucose, Lactate, Osmolality, and pH values during bioproduction.
Categories
Process control

Industry Need

Current process analytical techniques (PAT) in biomanufacturing are generally cost-prohibitive, ineffective, skill-intensive, and fail to support the growing demand for continuous manufacturing.

Approach

The team will address the current PAT by developing InSens4™ The team will address the current PAT by developing InSens4™, an in-line multi-analyte sensor that can simultaneous monitor Glucose, Lactate, osmolality, and pH values during bioproduction., an in-line multi-analyte sensor that can simultaneous monitor Glucose, Lactate, osmolality, and pH values during bioproduction.

Publications/Presentations

Sharma, R., Tathireddy, P., Kwan, B., Fournier, A., Smith, R., Robust, Multi-Analyte In-Line Sensor For Biomanufacturing, NIIMBL National Meeting, Jul 28, 2021.

Sharma, R., Tathireddy, P., Kwan, B., Fournier, A., Smith, R., Robust, Multi-Analyte In-Line Sensor For Biomanufacturing, NIIMBL National Meeting, Jul 28, 2021.

Sharma, R., Tathireddy, P., Kwan, B., Fournier, A., Smith, R., Robust, Multi-Analyte In-Line Sensor For Biomanufacturing, NIIMBL National Meeting, Jul 28, 2021.

Sharma, R., Tathireddy, P.,  Robust, Multi-Analyte In-Line Sensor for Biomanufacturing, Presented at BioProcess International Meeting, Sept 2021.

Tathireddy, P., Presenter, PC3.1-135 Multi-Analyte In-line Sensor for Biomanufacturing Applications Based on Analyte-Responsive Smart Hydrogels, NIIMBL National Meeting, Washington, D.C., July 26, 2022.

Impacts

Inline monitoring of critical process parameters enables greater process understanding and control, reduced product development times, and faster scale-up for the biopharma R&D.

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Project Lead

Applied Biosensors

Applied Biosensors

Participating Organizations

EMD Millipore Corporation

EMD Millipore Corporation

Merck Sharp & Dohme LLC

Merck Sharp & Dohme LLC