Current methods to reveal information on the health and productivity of cells used in the biomanufacturing processes include laborious processes steps and take several days to for analysis.
Apply existing genomic analysis technologies to identify changes in miRNA and/or mRNA expression in CHO that could be used to assay infection by adventitious agents.
By implementing a PCR-less rapid nucleic acid detection platform, an organization could reduce production downtime and contamination-related costs by avoiding up to one month of wasted manufacturing, enabling faster recovery, uninterrupted supply, and improved patient access.
Discovered a set of miRNA biomarkers whose expression levels correlate with adventitious viral infection.
Rapid CHO Transcriptome Analysis for Adventitious Agent Detection (PC2.2-105), NIIMBL Member Forum, Virtual, June 24, 2021.
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Carnegie Mellon University
EMD Millipore Corporation
Rensselaer Polytechnic Institute
