Development of a single-use disposable plastic device for clarifying cell culture broth from a disposable bioreactor, replacing the currently used centrifuge or depth filters, which get clogged very quickly.
Compact cell settler has been developed to recycle the settled live and productive cells from its bottom port back to bioreactor to achieve high cell densities in a continuous perfusion bioreactor. Settlers will be fabricated in single-use plastic and demonstrated for large-scale clarification.
Clarification of high cell density cultures
Advancement in upstream processing using single-use disposable bioreactors
Eased burden on downstream processing for high cell density cultures
Characterization of 24” single use plastic cell settler in cell culture experiments.
Glascock, C. & Kompala, D. (2024). Primary clarification of mammalian cell culture fluid using enhanced sedimentation on inclined surfaces inside the single-use disposable Sudhin BioSettler150. Biotechnology Progress. https://doi.org/10.1002/btpr.3489
Scale-up Studies on Single Use Settlers for Clarifying Cell Culture Broth (QSP1.0-018), NIIMBL Member Forum, Virtual, January 24, 2019.
Login to the NIIMBL member portal to access additional project information, including presentations, progress updates, reports, and more.
Not yet a member? Learn more about which level of NIIMBL membership is right for you and your organization.
Sudhin Biopharma Co
Genentech, Inc.
