Current sensor technologies are constrained by single-parameter detection, large size, and the need for frequent sample extraction. These limitations complicate integration and prevent real-time, in-situ monitoring, especially in milliliter-scale systems critical for early-stage research. Existing systems also struggle to meet the demands of continuous manufacturing and modular production facilities, where flexibility, scalability, and integration are essential. Regular fibers can tolerate typical sterilization doses (25–50 kGy) without structural damage; however, optical losses may increase due to radiation-induced attenuation (RIA), particularly in the visible range where attenuation can become significant.
The proposed sensor has the ability to monitor multiple parameters in real time. Its small size allows it to function effectively in milliliter-scale flasks, enabling detailed online sensing for research and development. In large-scale bioreactors, the sensor's distributed sensing capability enables flexible and customizable monitoring without requiring probes or openings, simplifying system design and enhancing process control. Polyimide-coated fibers will be used in non-sensing regions to provide radiation resistance and mechanical durability, while fluorine-doped fibers will be employed in the sensing region to minimize RIA and maintain signal integrity. Furthermore, the sensor's compatibility with gamma radiation ensures sterility, meeting industry standards for biomanufacturing.
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University of Massachusetts Lowell
Lonza Biologics, Inc.
Sartorius Stedim
Xheme
