The pharmaceutical industry continues to predominantly use batch processes due to the limitations of current technology, such as advanced control strategies and improved process monitoring. CM of biopharmaceuticals offers notable benefits compared to traditional batch production, such as increased agility, flexibility, improved quality, cost reductions, and social advantages. (Fisher et al. 2016) Therefore, reliable real-time monitoring sensors are crucial for pharmaceutical companies.
This project aims to develop an integrated Process Analytical Technology (PAT) for real time monitoring in biopharmaceutical manufacturing. The focus is on combining acoustofluidic device to enrich particles with Raman and Fourier Transform Infrared (FTIR) spectroscopy to create a spectro-acoustic PAT system. This innovative approach addresses the limitations of current monitoring techniques by providing real-time, nondestructive measurements with enhanced sensitivity.
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Purdue University
Merck Sharp & Dohme LLC
