NIPTE and Pfizer have teamed up to demonstrate the ability of TG-RS to reduce fluorescence and improve SNR of key metabolites in bioreactions. The superior SNR will enable the development and comparison of PLS and pure component models for the quantification of these metabolites during bioreactions of industrially relevant organisms.
Within this project, scale-up and integration of TG-RS for monitoring cell cultures in a bioreactor are conducted and robustness will be demonstrated through the modelling efforts to drive TG-RS utility in manufacturer capacities.
Anderson, C., Conference Participant, PC 5.2-134: Enhancing Analytical Sensitivity in Upstream Bioreactions Using Time-gated Raman Spectroscopy, NIIMBL National Meeting, Washington, D.C., June 26, 2025.
Anderson, Carl., Presenter, NIIMBL National Meeting conference, Washington D.C., June 25, 2025.
Anderson, Carl., Presenter, NIIMBL National Meeting conference, Washington D.C., June 26, 2025.
Use the real-time data collected during reactor monitoring as an input in a control strategy to maximize product yield and quality while minimizing inefficiencies that lead to product failure and loss of profit
Demonstrate the suitability of TG-RS for regulators as an appropriate process analytical technology (PAT) system
Create broad acceptance and implementation of TG-RS as an industry standard technology for bioreaction monitoring
Create broad acceptance and implementation of TG-RS as an industry standard technology for bioreaction monitoring
Broad acceptance and implementation of TG-RS as an industry standard technology for bioreaction monitoring
Work will demonstrate the suitability of TG-RS for regulators as an appropriate process analytical technology (PAT) system
TG-RS is expected to significantly improve the ability to monitor chemical conditions in bioreactors.
The real-time data collected during reactor monitoring can be used as an input in a control strategy to maximize product yield and quality while minimizing inefficiencies that lead to product failure and loss of profit.
Demonstrate that combining TG-RS and pure component modeling improves bioreaction monitoring capability while reducing calibration resource burden in a system ready for industrial deployment
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National Institute for Pharmaceutical Technology and Education, Inc (NIPTE)
Pfizer, Inc.
