Disposable single-use components are essential for biopharmaceutical manufacturing, unfortunately are commonly affected by contamination from extractables and leachables that adversely affect efficacy and quality.
The implementation of a diamond-like carbon coating could minimizes or eliminates the formation of leachables in single-use components.
Develop a standardized approach for depositing diamond like carbon coating on single use vessels to minimize the release of leachables
Minimize the need for extensive functional tests typically required for disposable vessels
Riley, P. R., Yang, K., Liu, Y., Skoog, S. A., Narayan, J., & Narayan, R. J. (2023). Effect of oxygen and fluorine plasma surface treatment of silicon-incorporated diamond-like carbon coatings on cellular responses of mouse fibroblasts. International Journal of Applied Ceramic Technology, 20(2), 879-883. https://doi.org/10.1111/ijac.14107
Riley, P., Joshi, P., Azizi Machekposhti, S., Sachan, R., Narayan, J., & Narayan, R. (2021). Enhanced Vapor Transmission Barrier Properties via Silicon-Incorporated Diamond-Like Carbon Coating. Polymers, 13. https://doi.org/10.3390/polym13203543
Movahed, S., Nguyen, A. K., Goering, P. L., Skoog, S. A., & Narayan, R. J. (2020). Argon and oxygen plasma treatment increases hydrophilicity and reduces adhesion of silicon-incorporated diamond-like coatings. Biointerphases, 15(4). https://doi.org/10.1116/6.0000356
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North Carolina State University
Genentech, Inc.
ILC Dover LP
