Project category: Drug substance

Continuous Countercurrent Spiral Chromatography (CCSC) – Feasibility, Demonstration and Commercialization

Inline Spiking Method for Validation of Virus Clearance in Continuous Bioprocessing

ADC Surrogates for Process Development

Mechanistic Modeling for Enhanced Chromatographic Productivity

Use of Metabolic Flux Analysis (MFA) to Expedite Media Selection and Optimization of CHO

A multiscale metabolic model for fed batch culture process control

Rapid Adventitious Agent Testing for Fail-Fast Process Decision-Making

Identification, Characterization and Removal of Host-Cell Proteins (HCP) in Chinese Hamster Ovary (CHO) Monoclonal Antibody Biomanufacturing Processes

Next Generation Sequencing (NGS) Internal Controls for Adventitious Agent Testing to Ensure Sensitivity for All Targets in Every Sample

At-Bioreactor Trace Metal Quantification and Statistical Process Control in CHO Cell-culture Production

Improved Lentiviral Vector Biomanufacturing for Cell and Gene Therapy Applications

Adaptive Process Control and Advanced Sensing for Robust mAb Glycan Quality