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NIIMBL supports innovative technology and workforce development projects that advance U.S. biopharmaceutical manufacturing capabilities and support a world-leading workforce.

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Modernizing clearance and quantification of host-cell proteins in mAb manufacture

To Improve reliability and quality assurance of the manufacturing processes through purification of monoclonal antibodies(mAbs) made by Chinese Hamster Ovary(CHO)

Automation and Control of a Precipitation-based Continuous Downstream Process for High Titer Products

A proposal to commercialize a continuous downstream process for monoclonal antibody production using precipitation and flowthrough chromatography. It aims to cut costs and boost sustainability. Led by RPI with top academic and industry partners.

Integrating High-Throughput Chromatography and Data Science in a Platform for the Rapid and Accurate Quantification of Full, Partial, and Empty AAV Capsids

Propose a platform to streamline the design of chromatographic methods for quantifying gene-loaded (full), partially loaded (partial), and empty Adeno-Associated Virus (AAV) capsids.

Development of Small Molecule Formulations for Enhanced Production of CAR-T Cell Therapies

This project targets challenges in biomanufacturing of cell and gene therapies, addressing inherent complexities and variabilities in biologically based production systems.

Optimizing Next Generation Sequencing for Sensitive Detection of Viral Adventitious Agents in Biologics

This study will evaluate short-read NGS technology for optimization of virus detection in a high complexity material, such as unprocessed bulk harvest.

Life Sciences Career Hub: Biomanufacturing in Central Massachusetts

The Life Sciences Career Hub: Biomanufacturing in Central Massachusetts program has been created to merge the biomanufacturing career awareness and access initiatives of MassBioEd and MBI.

Creation of National Standards for a Biomanufacturing Technician Registered Apprenticeship Program

Apprenti’s Biomanufacturing Technician Apprenticeship standards will establish a common framework, Apprenticeship Standards, which can be shared freely across the country to streamline development of regional programs.

Obtaining extensive in- and at-line input and output analytics combined with machine learning to improve predictive CQA

This project will combine an existing multiscale antibody titer and glycosylation model with a newly developed machine-learning integration to create a workflow that improves the efficient development of new antibody-expressing cell lines.

Spectro-acoustic process analytical technology for real-time monitoring of biopharmaceuticals

Development of an integrated Process Analytical Technology (PAT) for real time monitoring in biopharmaceutical manufacturing.

Rapid Bioburden and Sterility Testing for Biopharmaceutical Manufacturing

This project aims to develop and validate the Mango M6, a transformative system that addresses critical bottlenecks in biopharmaceutical manufacturing associated with bioburden and sterility testing.

Commercial Deployment of Integrated PAT Technologies to Enable Continuous Upstream Production of Glycosylated Monoclonal Antibodies

This project will develop and validate integrated online sampling process analytical technology (PAT) workflows to rapidly monitor biological drug critical quality attributes (CQAs).

SENSELINE: Single Fiber Solution for Real-Time Multi-Parameter Sensing in Bioprocessing

Developing miniature real-time multi-parameter sensor for Bioprocessing systems.

Showing 12 of 196 items

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Active Immunization Countermeasures

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Cell and Gene therapies

Data

Drug product

Drug substance

Equipment and Supplies

Incumbent worker training

Process control

Proteins/ Antibodies

Talent/ Pipeline development

A Bioelectronic Sensor for Rapid Assessment of Antibody Titer and Glycan Structure

A Day in the Life: Highlighting Careers in Biopharmaceutical Manufacturing

A Fully Continuous Downstream Process for High Titer Products

A Microlearning Capability for a Busy Biopharmaceutical Workforce

A Multiscale Metabolic Model for Fed Batch Culture Process Control

A Multivariate In-Line Optochemical Sensor Platform for Continuous Monitoring of Cross-Category Process Parameters and Product Attributes in Bioreactors

A New Generation of High-Efficiency HVAC Filters that Can Be Used with Existing Infrastructure to Stop the Spread of Coronavirus Through Recirculation of Air

A Novel Beads-Free CAR T-Cell Manufacturing Platform

A Novel Perfusion-Based 3D Bioreactor for Effective Selection, Activation, and Transduction of T-Cells for Immuno-Gene Therapy

A Public-Private Partnership Strategy for Workforce Training in Cell and Gene Therapy Manufacturing

A Transcriptome-Based Model for Improved CART Therapy

AAV Aggregation Testing Method Evaluation

Showing 12 of 196 items

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